Epithelioid hemangioendothelioma is a rare vascular neoplasm that can present with concurrent multiple organ involvement, which may cause diagnostic challenges.
Two cases highlight diagnostic challenges in rare multi-organ epithelioid hemangioendothelioma; extends sparse literature but leaves management questions open.
Epithelioid hemangioendothelioma is a rare vascular neoplasm of uncertain malignant potential. Various reports document metastatic or concurrent epithelioid hemangioendothelioma in several sites, most commonly with combined lung and liver involvement. The concurrent involvement of multiple sites at presentation may cause diagnostic problems because epithelioid hemangioendothelioma can mimic other neoplastic processes. Although it is a chemo-resistant disease, chemotherapy is usually advised for patients with metastatic or concurrent involvement. Here we document the presentation, treatment, and outcome of two cases with concurrent involvement of the lung and liver.
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Çelikel et al. (2007) studied this question.
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