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LPL modulation should not yet change dyslipidemia practice; leaves open validation of gene expression or stabilization strategies in trials.
The importance of lipoprotein lipase (LPL) in the regulation of overall lipid metabolism in humans and other animals is well documented. The major goal of this review is to identify and justify features that make LPL an important drug target for lipid management in particular for triglyceride lowering and HDL elevation, and propose strategies to modulate LPL activity.
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Sivaram Pillarisetti (2003) studied this question.
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