Abstract [3α-3H]-5α-Cholest-8(14)-en-3β-ol has been prepared by chemical synthesis. The incorporation of the label of this compound into liver cholesterol by intact rats has been demonstrated. The convertibility of 5α-cholest-8(14)-en-3β-ol to 5α-cholest-7-en-3β-ol and cholesterol by rat liver homogenates has been established. Upon incubation of [3α-3H]-5α-cholest-8(14)-en-3β-ol with a rat liver homogenate preparation under anaerobic conditions, the added substrate was recovered unchanged. The presence of a sterol with the expected properties of 5α-cholest-8(14)-en-3β-ol in rat skin has been demonstrated.
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Lee et al. (1969) studied this question.
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