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The activity of chicken brain phosphocholine diglyceride transferase was followed during pre‐ and postnatal development. The specific activity of this enzyme increases from the 10th day of embryonic life, reaches a maximum at hatching and decreases thereafter. Total brain activity increases in parallel with the increase of brain lecithins. The apparent Km of the enzyme for CDP choline is 1.5 × 10‐4m before the 10th day of embryonic life, 2.5 × 10‐5m between the 13th day of the embryo and the 10th day after hatching, and finally 1.3 × 10‐4m after the 38th day of postnatal life. These data suggest the existence of isoenzymes, one of which appears at the beginning of myelination.
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Freysz et al. (1972) studied this question.
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