Answers are grounded in this paper and cite their sources.
Here, we describe severe neuropsychiatric symptoms in an HIV-positive Asian man with extremely high efavirenz plasma levels while receiving standard treatment with efavirenz/tenofovir/emtricitabine fixed-dose regimen. Genetic examination revealed compound homozygosity for loss-of-function alleles of CYP2B6, including coding for a rare truncated protein. Neuropsychiatric symptoms resolved completely after efavirenz discontinuation.
No takes yet. Share an insight, caveat, or question.
Anagnostopoulos et al. (2013) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: