A novel three-dimensional mathematical model using similitude methods successfully simulates the electrical activity and complex cellular interactions within the rabbit sinoatrial node and atrial myocardium.
Model of rabbit SAN extends computational approaches to pacemaker activity; leaves open human translation pending validation.
This study focuses on possible applications of similitude design methods for three-dimensional simulation of the electrical activity of the sinoatrial node of the rabbit heart and the adjacent atrial myocardium. The proposed mathematical model has a hierarchical shape, where the relationship between the sinoatrial node and adjacent atrial myocardium is at the top and the dynamics of ion processes on the cardiomyocyte membranes is at the lower level of the model. Examples of using this three-dimensional model are given for the description of: (a) rhythm generation in the sinoatrial node of the heart; (b) the effect of doubling of the action potential duration in the site of the atrial myocardium with reduced electrical intercellular conductivity; and (c) the modulation effect of the electrical fibroblast–cardiomyocyte relationship on the peacemaker activity.
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V. V. Galanin (2021) studied this question.
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