Key result
A 3D whole-atrial model incorporating optimized generic ionic models successfully exhibited a spontaneously active sinoatrial node able to rhythmically excite the atria.
The study presents a generic tissue-based optimization process for ionic models, successfully applied to create a functional 3D computational model of atrial electrical activity.
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Supports computational atrial modeling; leaves open experimental validation and clinical translation.
Abed et al. (2013) studied this question. 3D atrial modeling with optimized ionic models was evaluated on Development of a spontaneously active SAN able to rhythmically excite the atria in a 3D model. A 3D whole-atrial model incorporating optimized generic ionic models successfully exhibited a spontaneously active sinoatrial node able to rhythmically excite the atria.
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