Key result
A generic cardiomyocyte ionic model was optimized using a multiobjective approach to accurately reproduce multiple action potential waveforms from rabbit cardiac tissue preparations.
A generic ionic model optimized with a multiobjective approach can accurately reproduce action potential waveforms and ionic currents across different types of cardiac myocytes.
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Facilitates refined computational modeling of rabbit cardiac electrophysiology; leaves open human validation and clinical translation.
Guo et al. (2013) studied this question. Generic cardiomyocyte ionic model was evaluated on Reconstruction of action potential waveforms. A generic cardiomyocyte ionic model was optimized using a multiobjective approach to accurately reproduce multiple action potential waveforms from rabbit cardiac tissue preparations.
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