The incidence of second primaries in 1,600 patients treated with radiotherapy for cancer of the larynx is reviewed. Carcinoma of the lung is the most frequent second primary with a significantly higher incidence in supraglottic laryngeal cancer. Because the follow-up of this irradiated population is limited it is not yet possible to estimate the risks of radiation-induced cancer in the entire life span following radiation treatment of cancer of the larynx.
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Marcus Brown (1978) studied this question.
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