What question did this study set out to answer?

To engineer a tumor-targeted nanoparticle system that modulates intra- and extracellular ion homeostasis to enhance radio-immunotherapy efficacy.

September 22, 2023Advanced ScienceOpen Access

Regulation of Ion Homeostasis for Enhanced Tumor Radio‐Immunotherapy

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To engineer a tumor-targeted nanoparticle system that modulates intra- and extracellular ion homeostasis to enhance radio-immunotherapy efficacy.
Synthesized liposome-coated, pH-responsive calcium carbonate nanoparticles loaded with a carbonic anhydrase inhibitor (CaCO3/CAI@Liposome, or CCL).
Investigated CCL decomposition, calcium release, and intracellular/extracellular pH shifts in the tumor microenvironment under X-ray exposure.
Evaluated systemic antitumor immune activation, including immunogenic cell death, dendritic cell maturation, and macrophage polarization.
CCL selectively decomposed in the acidic tumor microenvironment to release Ca2+ and CAI, simultaneously neutralizing extracellular acidity and elevating intracellular H+.
Intracellular proton accumulation combined with radiation-generated reactive oxygen species induced toxic calcium overload, markedly increasing tumor radiosensitivity.
Rebalancing tumor ion levels triggered robust immunogenic cell death, accelerated dendritic cell maturation, and polarized pro-tumor M2 macrophages into anti-tumor M1 phenotypes.

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Implication

Experimental study reveals enhanced radio-immunotherapy through pH and calcium regulation in tumors, highlighting a potent strategy to reverse immunosuppression.

Cite This Study

Qian et al. (2023) studied this question.

synapsesocial.com/papers/6a8cdfc44847f413e42f04b6 https://doi.org/10.1002/advs.202304092

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Implication

Experimental study reveals enhanced radio-immunotherapy through pH and calcium regulation in tumors, highlighting a potent strategy to reverse immunosuppression.

Regulation of Ion Homeostasis for Enhanced Tumor Radio‐Immunotherapy

Key Points

Discussion

Implication

Cite This Study

Regulation of Ion Homeostasis for Enhanced Tumor Radio‐Immunotherapy

Key Points

Discussion

Implication

Cite This Study

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