What question did this study set out to answer?

Establish a standardized and reproducible international unit for quantifying interferon-neutralizing antibodies across laboratories to evaluate patient immune responses.

November 11, 2003Neurology

Perspectives on the neutralization of interferons by antibody

View Full Paper

Ask AI

Bookmark

Authors

SGSidney E. GrossbergMedical College of Wisconsin

Discussion

Member takes

Implication

Methodological analysis reveals a standardized international unit for neutralizing antibodies in patient bioassays, highlighting improved cross-laboratory comparability.

Key Points

Establish a standardized and reproducible international unit for quantifying interferon-neutralizing antibodies across laboratories to evaluate patient immune responses.
Conducted experimental and theoretical analyses of interferon-antibody neutralization reactions.
Measured antibody neutralization capacity via in vitro human cell culture bioassays assessing the inhibition of receptor binding and signal transduction.
Established a defined international unit of interferon neutralizing antibody to resolve inconsistencies in titer reporting across different testing platforms.
Provided a quantitative basis to reliably assess neutralizing antibody prevalence and predict potential adverse clinical effects in patients receiving interferon therapies.

Cite This Study

Sidney E. Grossberg (2003) studied this question.

synapsesocial.com/papers/6a8ce096f64a4c3baf990bc3 https://doi.org/10.1212/01.wnl.0000092360.09423.e3

View Full Paper

Ask AI

Bookmark

Implication

Methodological analysis reveals a standardized international unit for neutralizing antibodies in patient bioassays, highlighting improved cross-laboratory comparability.

Perspectives on the neutralization of interferons by antibody

Discussion

Member takes

Implication

Key Points

Cite This Study

Perspectives on the neutralization of interferons by antibody

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider