What question did this study set out to answer?

To determine the contribution of classical cardiovascular risk factors to the occurrence of cardiovascular disease in patients diagnosed with heterozygous familial hypercholesterolaemia.

November 19, 2004Journal of Internal MedicineOpen Access

The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients

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Authors

AJAngelique C.M. JansenAlrijne Ziekenhuis MTMichael W.T. TanckElectrophysiology MTMieke D. TripFolkhälsans Forskningscentrum

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Implication

Retrospective cohort study finds classical risk factors predict cardiovascular disease in familial hypercholesterolaemia, highlighting the necessity of intervention beyond statins.

Key Points

To determine the contribution of classical cardiovascular risk factors to the occurrence of cardiovascular disease in patients diagnosed with heterozygous familial hypercholesterolaemia.
Conducted a retrospective, multicenter cohort study of N=2,400 heterozygous familial hypercholesterolaemia patients across 27 Dutch lipid clinics, diagnosed by low-density lipoprotein receptor mutations or strict clinical criteria.
Gathered clinical data via medical records and questionnaires, evaluating cardiovascular mortality and events across 112,943 person-years using multivariate Cox regression analysis.
A total of 782 patients (32.6%) developed at least one cardiovascular event during 112,943 person-years of follow-up.
Independent clinical predictors of cardiovascular disease included male sex (RR 2.82, 95% CI 2.37–3.36), smoking (RR 1.67, 95% CI 1.40–1.99), hypertension (RR 1.36, 95% CI 1.06–1.75), and diabetes mellitus (RR 2.19, 95% CI 1.36–3.54).
Low HDL cholesterol (RR 1.37, 95% CI 1.15–1.63) and elevated lipoprotein(a) levels (RR 1.50, 95% CI 1.20–1.79) were also independent risk factors, with all six factors accounting for 18.7% of cardiovascular disease variance.

Cite This Study

Jansen et al. (2004) studied this question.

synapsesocial.com/papers/6a8ce0f10fc8325511ff1569 https://doi.org/10.1111/j.1365-2796.2004.01405.x

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Implication

Retrospective cohort study finds classical risk factors predict cardiovascular disease in familial hypercholesterolaemia, highlighting the necessity of intervention beyond statins.

The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients

Discussion

Member takes

Implication

Key Points

Cite This Study

The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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