Please release me: Supercritical carbon dioxide was used as an antisolvent for the formation of nanoparticles that contain luciferin, a bioactive therapeutic, dispersed in poly(lactic acid) (PLA), a biodegradable polymer. These nanoparticles undergo slow and sustained drug release, which can be monitored by bioluminescence both in vitro and in vivo (see picture; ATP=adenosine triphosphate; ADP=adenosine diphosphate; Pi=inorganic phosphate).
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Jacobson et al. (2008) studied this question.
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