Which is the best antiaggregant or anticoagulant therapy after TAVI? A propensity-matched analysis from the ITER registry. The management of DAPT after TAVI
Why the study?
Does aspirin alone reduce complications and valve dysfunction compared to DAPT in patients undergoing TAVI with a balloon-expandable prosthesis?
Population
1,364 consecutive patients undergoing transcatheter aortic valve implantation with a balloon-expandable…
Comparison
Aspirin alone (single antiplatelet therapy) vs Dual antiplatelet therapy (DAPT)
Design
Cohort
Follow-up
45±14 months
Authors
Discussion
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Member takes
Implication
Draft the Implication (Iterative Process):**.
Structured PICO
Does aspirin alone reduce complications and valve dysfunction compared to DAPT in patients undergoing TAVI with a balloon-expandable prosthesis?
P
Population
1,364 consecutive patients undergoing transcatheter aortic valve implantation (TAVI) with a balloon-expandable prosthesis enrolled in the ITER registry (605 per group after propensity matching).
I
Intervention
Aspirin alone (single antiplatelet therapy)
C
Comparator
Dual antiplatelet therapy (DAPT)
O
Outcome
Prosthetic heart valve dysfunction at follow-up (45±14 months)hard clinical
In patients undergoing TAVI with a balloon-expandable prosthesis, aspirin alone compared to DAPT reduces 30-day mortality and bleeding without increasing the risk of long-term prosthetic valve dysfunction.
Cite This Study
D’Ascenzo et al. (2017) studied this question.