Are the days of C2 symmetric ligands as chiral inductors numbered? Reports of the record selectivities achieved with the ligands 1 and 2 in Pd-catalyzed allylic substitutions (A. Pfaltz et al., this issue, p. 566) could lead to this conclusion. Their results indicate that not only steric but also stereoelectronic effects are important for these reactions.
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Oliver Reiser (1993) studied this question.
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