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The key to the cells: The N-terminal organometallic complex shown greatly improves cellular uptake of a bioconjugate containing the NLS peptide (NLS=nuclear localization sequence) and cobaltocenium carboxylic acid. Nuclear localization of this novel organometallic bioconjugate in HepG2 cells is demonstrated by live-cell fluorescence microscopy (see picture). FITC=fluorescein isothiocyanate.
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Wüstholz et al. (2005) studied this question.
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