Potassium homeostasis in patients with atrial fibrillation
Why the study?
Do abnormal serum potassium levels increase short-term mortality in patients with atrial fibrillation co-treated with diuretics and rate- or rhythm-controlling drugs?
Population
Danish patients with newly diagnosed atrial fibrillation or flutter co-treated with diuretics and…
Comparison
Abnormal serum potassium levels vs Reference serum potassium level of 4.1-4.4 mmol/L
Design
Editorial
Follow-up
90 days post-discharge
Authors
Discussion
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Implication
A U-shaped association exists between serum potassium levels and short-term mortality in AF patients on diuretics and rate/rhythm control, suggesting an optimal target of 4.1-4.4 mmol/L.
Structured PICO
Do abnormal serum potassium levels increase short-term mortality in patients with atrial fibrillation co-treated with diuretics and rate- or rhythm-controlling drugs?
P
Population
Danish patients with newly diagnosed atrial fibrillation (AF) or flutter co-treated with diuretics and rate-/rhythm-controlling agents (n > 14,000)
I
Intervention
Abnormal serum potassium levels (overt hypokalemia <3.5 mmol/L, hyperkalemia >5.0 mmol/L, low-normal 3.5-3.7 mmol/L, and slightly raised 4.5-4.7 mmol/L)
C
Comparator
Reference serum potassium level of 4.1-4.4 mmol/L
O
Outcome
All-cause mortality at 90 days post-dischargehard clinical
A U-shaped association exists between serum potassium levels and short-term mortality in AF patients on diuretics and rate/rhythm control, suggesting an optimal target of 4.1-4.4 mmol/L.
Cite This Study
Chan et al. (2019) studied this question.