January 30, 2010AJP Heart and Circulatory Physiology

Reduced mechanical efficiency of rat papillary muscle related to degree of hypertrophy of cardiomyocytes

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Population

Isolated rat papillary muscles of the right ventricle

Comparison

Right ventricular hypertrophy induced by… vs Control rat papillary muscles

Design

Preclinical

Authors

YWYeun Ying WongMayo Clinic in Arizona MHM. Louis HandokoHeart Failure & Transplant KMKoen T. B. MouchaersAmsterdam UMC Location Vrije Universiteit Amsterdam

Discussion

Member takes

Implication

Should not yet change clinical practice; hypothesis-generating for cellular efficiency loss in human heart failure.

Structured PICO

Population

Isolated rat papillary muscles of the right ventricle (n=18 total; 7 control, 11 hypertrophied via monocrotaline injection causing pulmonary hypertension)

Intervention

Right ventricular hypertrophy induced by monocrotaline injection

Comparator

Control rat papillary muscles

Outcome

Net mechanical efficiency (ratio of work output and suprabasal O2 uptake)surrogate

Cardiomyocyte hypertrophy directly reduces mechanical efficiency at the cellular level, which may partly explain reduced myocardial efficiency in chronic heart failure.

Cite This Study

Wong et al. (2010) studied this question.

synapsesocial.com/papers/6a8cf3051af30e2244eaa4ee https://doi.org/10.1152/ajpheart.00773.2009

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Reduced mechanical efficiency of rat papillary muscle related to degree of hypertrophy of cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Reduced mechanical efficiency of rat papillary muscle related to degree of hypertrophy of cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider