March 1, 1974Science

Human DNA Polymerase III (R-DNA Polymerase): Distinction from DNA Polymerase I and Reverse Transcriptase

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Population

Human lymphoblasts

Comparison

Separation and characterization of DNA… vs DNA polymerase I and viral reverse transcriptase…

Design

Preclinical

Authors

BLB.J. LewisYouth Development JAJohn W. AbrellNational Institutes of Health RSR. Graham SmithTulane University

Discussion

Member takes

Implication

Caution against clinical extrapolation; leaves open Pol III as distinct target in mammalian replication research.

Structured PICO

Population

Human lymphoblasts

Intervention

Separation and characterization of DNA polymerase III

Comparator

DNA polymerase I and viral reverse transcriptase from a primate type C virus

Outcome

Biochemical and immunological distinction of DNA polymerase III

The study demonstrates the successful isolation of human DNA polymerase III and establishes its biochemical and immunological distinction from DNA polymerase I and viral reverse transcriptase.

Cite This Study

Lewis et al. (1974) studied this question.

synapsesocial.com/papers/6a8cf37b286a877edd968135 https://doi.org/10.1126/science.183.4127.867

View Full Paper

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Human DNA Polymerase III (R-DNA Polymerase): Distinction from DNA Polymerase I and Reverse Transcriptase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Human DNA Polymerase III (R-DNA Polymerase): Distinction from DNA Polymerase I and Reverse Transcriptase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider