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June 1, 1985Biochemical JournalOpen Access

Evidence that non-covalent forces, thiol and disulphide groups affect the structure and binding properties of the prolactin receptor on hepatocytes from pregnant rats

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Population

Hepatocytes from pregnant rats

Comparison

Incubation with dithiothreitol or N-ethylmaleimide vs Control

Design

Preclinical

Authors

KYKenneth M. YamadaSetsunan UniversityDDDavid B. DonnerBaker Heart and Diabetes Institute

Discussion

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Implication

Should not change clinical practice; leaves open thiol regulation of prolactin receptors in human hepatocytes.

Structured PICO

P
Population
Hepatocytes from pregnant rats
I
Intervention
Incubation with dithiothreitol or N-ethylmaleimide
C
Comparator
Control
O
Outcome
Specific 125I-prolactin bindingsurrogate

Thiol and disulphide groups are present in the prolactin receptor and regulate the formation and properties of prolactin receptor complexes in pregnant rat hepatocytes.

Cite This Study

Yamada et al. (1985) studied this question.

synapsesocial.com/papers/6a8cf46242b2f342f8279470https://doi.org/10.1042/bj2280383
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY1963 · 10,183 citations
  2. 2Solubilization and Molecular Weight Estimation of Prolactin Receptors from Rana catesbeiana Tadpole Liver and Tail Fin*1981 · 22 citations
  3. 3Binding sites for lactogenic and somatogenic hormones from rabbit mammary gland and liver.1983 · 125 citations
  4. 4Different characteristics of solubilized lactogen receptors from livers of pregnant and non-pregnant female rats1982 · 22 citations
  5. 5Isolation and properties of the electrophoretic components of human growth hormone by Sephadex-gel filtration and preparative polyacrylamide-gel electrophoresis1966 · 28 citations