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Passing on information. Two conformational switches, decalin units, were coupled to a 14-membered bislactam ring (see formula, TBDPS=tert-butyldiphenylsilyl). Removal of a bisacetal clamp on the left side of the molecule resulted in a double ring-flip of the left decalin unit. Conformational coupling through the bislactam unit led to a double ring-flip in the right decalin unit.
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Karle et al. (2003) studied this question.
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