Inhibition of Soluble Epoxide Hydrolase Attenuated Atherosclerosis, Abdominal Aortic Aneurysm Formation, and Dyslipidemia

Six-month-old apolipoprotein E-deficient mice chronically infused with angiotensin II (1.44 mg/kg/d) for 4 weeks to induce abdominal aortic aneurysm (AAA), accelerate atherosclerosis development and carotid artery ligation-induced vascular remodeling

s-EH inhibitor AR9276 (1.5 g/L in drinking water) for 4 weeks

Vehicle for 4 weeks

Rate of AAA formation, atherosclerotic lesion area, and ligation-induced carotid artery remodelingsurrogate