Echocardiography and laboratory testing should be considered in asymptomatic monozygotic twins of patients with Kawasaki disease to detect subclinical coronary vasculitis.
Supports screening consideration in asymptomatic monozygotic twins of Kawasaki disease patients; leaves open prospective validation before practice change.
Multiple lines of evidence suggest that susceptibility to Kawasaki disease (KD) is influenced by host genetics. Subclinical coronary artery vasculitis may be present in monozygotic twins who are discordant for clinical signs of KD. Health care providers should consider laboratory testing and echocardiography in both monozygotic twins when only one twin presents with clinical KD.
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Kottek et al. (2011) studied this question.
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