This case highlights that typical Kawasaki Disease with coronary involvement can develop as early as day 1 and resolve completely with prompt administration of aspirin and steroids.
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Suggests possible benefit of prompt therapy in early Kawasaki coronary involvement; hypothesis-generating and should not change practice.
Kawasaki disease (KD) is an acute, self-limited, inflammatory disease affecting medium-sized arteries and particularly the coronary arteries in about 25% of untreated cases. KD is a clinical diagnosis based on the presence of ≥5 days of fever and the presence of ≥4 of the 5 principal clinical criteria. We described, for the first time to our knowledge, a case of a very early development (on day 1) of typical KD with transient coronary involvement, diagnosed on day 2 of disease and treated with aspirin and steroids on day 3, with complete resolution of clinical signs and coronary involvement.
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Buonsenso et al. (2018) studied this question.
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