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December 22, 2020MedicineOpen Access

Peripheral follicular cytotoxic T -like cells in Kawasaki disease with coronary artery aneurysms

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Why the study?

Infiltration of CD8+ T cells plays an essential role in coronary aneurysm formation in Kawasaki disease, but the role of follicular cytotoxic T cells is unclear.

Population

2 KD children with sustained coronary artery aneurysms

Design

Case report

Authors

MXMeng XuUniversity of Illinois Urbana-ChampaignJLJinxiang LiuBeijing Institute of TechnologyPLPan LuNingxia Medical University

Discussion

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Implication

Tfc expansion may mark persistent CAA in KD; hypothesis-generating observation needing larger validation.

Structured PICO

P
Population
2 boys (ages 3 years and 6 months) with Kawasaki disease and sustained coronary artery aneurysms
I
Intervention
Intravenous immunoglobulin and oral aspirin (Case 1 also received a second infusion of intravenous immunoglobulin, intravenous prednisolone, and low-molecular-weight heparin)
O
Outcome
Regression of coronary artery aneurysms and occurrence of cardiovascular eventssurrogate

Follicular cytotoxic T cells may be associated with the formation of coronary artery aneurysms in children with Kawasaki disease.

Limitations

  • Small sample size
  • Lack of functional analysis

Cite This Study

Xu et al. (2020) studied this question.

synapsesocial.com/papers/6a8cfbb91b953290645c2163https://doi.org/10.1097/md.0000000000023714

Topics

Dual antiplatelet therapy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mortality Among Japanese With a History of Kawasaki Disease: Results at the End of 20092013 · 56 citations
  2. 2CD8 T LYMPHOCYTES DO NOT EXPRESS CYTOTOXIC PROTEINS IN CORONARY ARTERY ANEURYSMS IN ACUTE KAWASAKI DISEASE2005 · 14 citations
  3. 3High-dimensional single cell analysis identifies stem-like cytotoxic CD8+ T cells infiltrating human tumors2018 · 350 citations
  4. 4Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies2017 · 169 citations
  5. 5CXCR5<sup>+</sup> CCR7<sup>–</sup> CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles2007 · 161 citations