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April 1, 2003Pediatrics International

Inducible and endothelial constitutive nitric oxide synthase gene polymorphisms in Kawasaki disease

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Why the study?

Are ecNOS and iNOS gene polymorphisms associated with the development of coronary artery lesions in Japanese patients with Kawasaki disease?

Population

Japanese patients with Kawasaki disease (with or without coronary artery lesions) and controls

Comparison

Endothelial constitutive NOS and inducible NOS… vs Controls and Kawasaki disease patients without…

Design

Case-control

Authors

VKVahid KhajoeeBrooklyn Hospital CenterHKHidehiko KariyazonoFukuoka Children's Hospital and Medical Center for Infectious DiseasesTOTakuro OhnoKokura Memorial Hospital

Discussion

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Implication

No association with coronary lesions in this Japanese cohort; leaves open genetic roles pending larger studies.

Structured PICO

Are ecNOS and iNOS gene polymorphisms associated with the development of coronary artery lesions in Japanese patients with Kawasaki disease?

P
Population
Japanese patients with Kawasaki disease (with or without coronary artery lesions) and controls
I
Intervention
Endothelial constitutive NOS (ecNOS) and inducible NOS (iNOS) gene polymorphisms
C
Comparator
Controls and Kawasaki disease patients without coronary artery lesions
O
Outcome
Development of coronary artery lesions (CAL)surrogate

This study found no association between ecNOS or iNOS gene polymorphisms and the development of coronary artery lesions in Japanese patients with Kawasaki disease.

Cite This Study

Khajoee et al. (2003) studied this question.

synapsesocial.com/papers/6a8cfc02ea63fdd6cbf555f5https://doi.org/10.1046/j.1442-200x.2003.01684.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vascular Endothelial Growth Factor/Vascular Permeability Factor Augments Nitric Oxide Release From Quiescent Rabbit and Human Vascular Endothelium1997 · 405 citations
  2. 2Molecular mechanisms and therapeutic strategies related to nitric oxide1995 · 785 citations
  3. 3Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.1997 · 1,193 citations
  4. 4Fortnightly Review Biology and clinical relevance of nitric oxide1994 · 140 citations