Why the study?
Does real-time fluorescent RT-PCR improve the detection of hepatitis E virus compared to conventional RT-PCR in clinical samples?
Population
Sera from 646 individuals, as well as serial dilutions of HEV genotypes 1 and 4.
Comparison
Real-time fluorescent RT-PCR assay vs Conventional RT-PCR assay
Design
Cross-sectional
Authors
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Real-time RT-PCR may improve HEV detection in non-A-C hepatitis; leaves open whether it changes management or needs prospective validation.
Does real-time fluorescent RT-PCR improve the detection of hepatitis E virus compared to conventional RT-PCR in clinical samples?
Real-time fluorescent RT-PCR is more sensitive than conventional RT-PCR for detecting hepatitis E virus, particularly genotype 4, which is prevalent in northern China.
Zhao et al. (2007) studied this question.
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