Early use of corticosteroids is suggested for drug-induced lupus erythematosus associated with severe pericarditis and potential pericardial tamponade.
May support early corticosteroids in refractory drug-induced lupus tamponade; hypothesis-generating from single case, needs prospective validation.
A patient with suspected isoniazid-induced lupus erythematosus had positive reaction for antinuclear antibody, lupus erythematosus cell, gamma and nongamma direct antiglobulin tests. Severe pericarditis with life-threatening pericardial tamponade required emergency pericardiocentesis. Recurrence of the pericardial effusion with tamponade necessitated use of corticosteroids. We suggest use of steroids early in drug-induced lupus erythematosus, if associated with severe pericarditis with any question of pericardial tamponade (even in the face of underlying tuberculosis).
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Joseph Greenberg (1972) studied this question.
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