Why the study?
Does procainamide induce antinuclear antibodies and lupus syndrome in patients treated for cardiac arrhythmias?
Population
16 patients treated for cardiac arrhythmias
Design
Cohort
Authors
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Procainamide use may warrant monitoring for lupus-like symptoms; extends evidence of drug-induced autoimmunity beyond genetic predisposition.
Does procainamide induce antinuclear antibodies and lupus syndrome in patients treated for cardiac arrhythmias?
A high proportion of patients treated with procainamide develop antinuclear antibodies, suggesting the drug-induced lupus response is not limited to those with genetic predisposition.
Blomgren et al. (1969) studied this question.
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