Why the study?
Do genetic and metabolic factors influence susceptibility to procainamide-related autoimmunity in patients treated for cardiac arrhythmias?
Population
Patients on long-term procainamide for various cardiac arrhythmias
Comparison
Procainamide vs Controls (not further specified)
Design
Cohort
Follow-up
long-term
Authors
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May flag procainamide autoimmunity risk via HLA-DQw7 and C4 alleles in arrhythmia patients; leaves open prospective validation before testing.
Do genetic and metabolic factors influence susceptibility to procainamide-related autoimmunity in patients treated for cardiac arrhythmias?
Certain genetic factors (DQw7, C4 null alleles) and oxidative metabolism markers may serve as predictors for procainamide-related autoimmunity.
Adams et al. (1993) studied this question.
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