Why the study?
Does procainamide induce serologic changes in asymptomatic cardiac patients compared to quinidine or controls?
Population
Cardiac patients with no manifestations of drug-induced lupus
Comparison
Procainamide for 6 weeks or more vs Quinidine and age- and sex-matched controls
Design
Cohort
Follow-up
6 weeks or more
Authors
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Procainamide was associated with frequent autoantibody induction in asymptomatic patients; leaves open clinical significance and need for prospective monitoring studies.
Does procainamide induce serologic changes in asymptomatic cardiac patients compared to quinidine or controls?
Procainamide therapy for 6 weeks or more frequently induces autoantibodies (LE cells, anti-DNP, anti-DNA) even in asymptomatic cardiac patients.
Molina et al. (1969) studied this question.
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