Why the study?
Does acetylprocainamide therapy cause recurrence of lupus syndrome in patients with previous procainamide-induced lupus syndrome?
Population
11 patients with previous procainamide-induced lupus syndrome being treated for cardiac arrhythmias
Design
Case_series
Authors
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May support acetylprocainamide in prior procainamide-induced lupus; leaves open prospective confirmation of low recurrence risk.
Does acetylprocainamide therapy cause recurrence of lupus syndrome in patients with previous procainamide-induced lupus syndrome?
Acetylprocainamide can be used to treat arrhythmias in patients with prior procainamide-induced lupus without typically causing lupus recurrence, supporting the hypothesis that the aromatic amino group in procainamide is responsible for the lupus-inducing effect.
Jeffrey Kluger (1981) studied this question.
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