Why the study?
Is acetylprocainamide a safer antiarrhythmic agent than procainamide?
Is acetylprocainamide a safer antiarrhythmic agent than procainamide?
Acetylprocainamide is highlighted as a potentially safer antiarrhythmic alternative to procainamide based on theoretical and early clinical experience.
Answers are grounded in this paper and cite their sources.
Should not yet change procainamide prescribing; leaves open hypothesis that acetylprocainamide may be safer by acetylator status.
In conclusion, it was the differential responses of slow and rapid acetylators to procainamide therapy that gave the initial clues that acetylprocainamide might be a safer drug than procainamide. So far, the experience with acetylprocainamide has been encouraging.
No takes yet. Share an insight, caveat, or question.
Drayer et al. (1979) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: