Why the study?
Does N-acetylprocainamide have different electrophysiological effects compared to procainamide in the anaesthetized dog heart?
Population
Anaesthetized dogs
Comparison
N-acetylprocainamide vs Procainamide
Design
Preclinical
Authors
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Supports distinct electrophysiological effects of N-acetylprocainamide in dogs; leaves open clinical translation for human arrhythmia therapy.
Does N-acetylprocainamide have different electrophysiological effects compared to procainamide in the anaesthetized dog heart?
N-acetylprocainamide, the major metabolite of procainamide, exhibits distinct electrophysiological properties in the dog heart, notably lacking the conduction-delaying effects on the His-Purkinje system and AV node seen with the parent drug.
Amlie et al. (1978) studied this question.
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