Key result
N-acetylprocainamide increases myocardial contraction force, whereas procainamide has a negative inotropic effect.
Why the study?
Does N-acetylprocainamide compared to procainamide affect myocardial contractile force, heart rate, and blood pressure in anesthetized dogs?
Population
Open-chest, vagotomized, pentobarbital-anesthetized dogs
Comparison
N-acetylprocainamide at doses up to 40 mg/kg vs Procainamide (PA) at doses of 10-40 mg/kg
Design
Preclinical
Authors
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Warrants caution against extrapolating canine inotropy to patients; leaves open metabolite-specific benefits in human antiarrhythmic use.
Does N-acetylprocainamide compared to procainamide affect myocardial contractile force, heart rate, and blood pressure in anesthetized dogs?
In a canine model, N-acetylprocainamide demonstrated positive inotropic effects at high doses, contrasting with the negative inotropic effects of procainamide, though both agents lowered heart rate and blood pressure.
Lertora et al. (1979) studied this question. N-acetylprocainamide (NAPA) vs. Procainamide (PA) was evaluated on Myocardial force of contraction. N-acetylprocainamide increased myocardial force of contraction, particularly at 40 mg/kg, whereas procainamide had a negative inotropic effect at all doses (10-40 mg/kg).
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