Why the study?
Does N-acetylprocainamide alter myocardial contractile force in anesthetized dogs?
Population
Chloralose-urethane anesthetized dogs
Comparison
N-acetylprocainamide low dose and high dose vs Pretreatment with propranolol or propranolol…
Design
Preclinical
Authors
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Animal data on NAPA's indirect inotropy should not alter clinical practice; leaves open mechanistic studies of its negative effects under beta-blockade.
Does N-acetylprocainamide alter myocardial contractile force in anesthetized dogs?
The positive inotropic actions of N-acetylprocainamide in dogs are indirect, mediated by vagolytic properties at low doses and catecholamines at high doses, with an underlying direct negative inotropic effect unmasked by beta-blockade.
Lertora et al. (1986) studied this question.
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