Antiarrhythmic efficacy of N‐acetylprocainamide in patients with premature ventricular contractions

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Why the study?

Does oral N-acetylprocainamide (NAPA) improve antiarrhythmic efficacy in patients with premature ventricular contractions?

Population

9 patients with premature ventricular contractions (PVCs)

Design

Case_series

Authors

Discussion

Suggests NAPA response may be limited to coupled PVCs; hypothesis-generating case report data requiring prospective validation.

Does oral N-acetylprocainamide (NAPA) improve antiarrhythmic efficacy in patients with premature ventricular contractions?

Population

9 patients with premature ventricular contractions (PVCs)

Intervention

Oral administration of a 1.5-gm dose of N-acetylprocainamide (NAPA)

Outcome

Antiarrhythmic efficacy (response to therapy)surrogate

Oral N-acetylprocainamide demonstrates antiarrhythmic efficacy specifically in patients with coupled premature ventricular contractions.

Lee et al. (1976) studied this question.

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