Why the study?
Does long-term N-acetylprocainamide therapy reduce the frequency of premature ventricular complexes in patients with chronic ventricular arrhythmias?
Population
4 patients with chronic ventricular arrhythmias, shown to respond over the short term to N-acetylprocainamide
Comparison
N-acetylprocainamide administered for between 3… vs Placebo administered at 6-month intervals when…
Design
Case_series
Follow-up
3 to 4 years
Authors
Loading...
May support sustained PVC suppression with long-term NAPA without tolerance; hypothesis-generating and requires randomized confirmation before clinical use.
Does long-term N-acetylprocainamide therapy reduce the frequency of premature ventricular complexes in patients with chronic ventricular arrhythmias?
Long-term N-acetylprocainamide therapy maintains its antiarrhythmic effect without tolerance development in patients with chronic ventricular arrhythmias.
Atkinson et al. (1983) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: