Why the study?
Does N-acetylprocainamide improve clinical response in patients with resistant chronic ventricular arrhythmias?
Population
10 patients with chronic ventricular arrhythmias who had not responded to usual doses of currently available…
Comparison
N-acetylprocainamide (NAPA) repeated dosing vs baseline therapy
Design
Case_series
Authors
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NAPA ineffective with frequent adverse effects in resistant ventricular arrhythmias; leaves open whether kinetic modeling warrants prospective evaluation.
Does N-acetylprocainamide improve clinical response in patients with resistant chronic ventricular arrhythmias?
N-acetylprocainamide was not clinically effective and caused frequent adverse effects in patients with resistant chronic ventricular arrhythmias, although patient-specific kinetic modeling was feasible.
Rodman et al. (1982) studied this question.
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