July 1, 1987Clinical Pharmacology & Therapeutics

Effect kinetics of N-acetylprocainamide-induced QT interval prolongation

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Why the study?

Does N-acetylprocainamide-induced QT interval prolongation predict clinical response in patients with stable chronic ventricular arrhythmias?

Population

n=5 patients with stable chronic ventricular arrhythmias

Design

Case_series

Authors

APAntoni A PiergiesNorthwestern University TRTsuen Ih RuoNorthwestern University EJEllen M JansynNorthwestern University

Discussion

Member takes

Implication

Initial QTc changes should not guide NAPA use in ventricular arrhythmias; this case report leaves predictive utility unresolved.

Structured PICO

Does N-acetylprocainamide-induced QT interval prolongation predict clinical response in patients with stable chronic ventricular arrhythmias?

Population

n=5 patients with stable chronic ventricular arrhythmias

Intervention

N-acetylprocainamide (NAPA) 15 mg/kg dose

Outcome

Changes in corrected QT interval (QTc) and correlation with clinical responsesurrogate

QT interval changes during initial N-acetylprocainamide administration do not reliably predict subsequent clinical response in patients with ventricular arrhythmias.

Cite This Study

Piergies et al. (1987) studied this question.

synapsesocial.com/papers/6a88fbd799b67c6b3e1fedaa https://doi.org/10.1038/clpt.1987.117

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Effect kinetics of N-acetylprocainamide-induced QT interval prolongation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect kinetics of N-acetylprocainamide-induced QT interval prolongation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider