Why the study?
Does short-term oral N-acetylprocainamide suppress premature ventricular contractions in patients with chronic PVCs?
Population
10 patients with chronic premature ventricular contractions (PVCs)
Comparison
Short-term oral N-acetylprocainamide… vs Placebo
Design
Other
Follow-up
short-term
Authors
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Should not yet change PVC management practice; leaves open NAPA's role as a hemodynamically neutral option pending larger trials.
Does short-term oral N-acetylprocainamide suppress premature ventricular contractions in patients with chronic PVCs?
Short-term oral N-acetylprocainamide effectively suppresses premature ventricular contractions without causing myocardial depression, though it may cause gastrointestinal side effects and insomnia.
Atkinson et al. (1977) studied this question.
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