Key result
Oral N-acetylprocainamide was 78.0% absorbed, and interindividual variation in absorption correlated with fast intercompartmental clearance (r = 0.89, p = 0.045).
Why the study?
What are the pharmacokinetic properties of N-acetylprocainamide in patients with ventricular arrhythmias?
Population
5 patients with ventricular arrhythmias
Design
Case_series
Authors
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NAPA oral absorption averages 78% but varies with intercompartmental clearance; leaves open whether hemodynamics affect bioavailability in arrhythmia patients.
What are the pharmacokinetic properties of N-acetylprocainamide in patients with ventricular arrhythmias?
Effect estimate: r = 0.89
p-value: p=0.045
The bioavailability of N-acetylprocainamide may be affected by hemodynamic changes, as its absorption correlates with fast intercompartmental clearance.
Atkinson et al. (1989) studied ventricular arrhythmias (n=5). N-acetylprocainamide was evaluated on NAPA absorption and disposition (r = 0.89, p=0.045). Oral N-acetylprocainamide was 78.0% absorbed, and interindividual variation in absorption correlated with fast intercompartmental clearance (r = 0.89, p = 0.045).
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