Why the study?
Does sustained-release procainamide reduce ventricular ectopic activity?
Does sustained-release procainamide reduce ventricular ectopic activity?
Sustained-release procainamide is effective in reducing ventricular ectopic activity, though larger trials are needed to confirm long-term efficacy and safety.
A sustained-release preparation of procainamide (PAD) was evaluated in a double-blind cross-over study. The preparation was found to reduce ventricular ectopic activity in all seven patients who completed the investigation in five patients the effectiveness reached the defined level of significance. A larger clinical trial to assess the long-term use of this preparation in terms of efficacy, safety and convenience is recommended.
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Bauer et al. (1977) studied this question.
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