Why the study?
Does aspirin reduce myocardial release of thromboxane B2 and ventricular ectopic activity following acute coronary artery occlusion in dogs?
Population
Anaesthetized open-chest greyhounds undergoing acute coronary artery occlusion
Design
Preclinical
Follow-up
Early post-occlusion (measured at 2 min post-occlusion)
Authors
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Supports TxB2 role in canine post-occlusion arrhythmias; hypothesis-generating and should not change human practice.
Does aspirin reduce myocardial release of thromboxane B2 and ventricular ectopic activity following acute coronary artery occlusion in dogs?
In a canine model of acute coronary occlusion, intravenous aspirin suppressed thromboxane B2 release and ventricular ectopic activity, suggesting TxB2 contributes to early post-infarction arrhythmias.
Coker et al. (1981) studied this question.
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