Why the study?
Does aspirin increase coronary collateral flow after acute coronary occlusion in dogs?
Population
13 open-chest dogs with acute occlusion of the left anterior descending coronary artery
Comparison
Aspirin 600 mg i.v. administered 1 hour before… vs Control dogs (no aspirin)
Design
Preclinical
Follow-up
4 hours after occlusion
Authors
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No immediate clinical implications for acute coronary syndromes; leaves open whether aspirin enhances epicardial collaterals in humans.
Does aspirin increase coronary collateral flow after acute coronary occlusion in dogs?
Aspirin administration prior to acute coronary occlusion in dogs significantly increases epicardial collateral blood flow over 4 hours.
Capurro et al. (1979) studied this question.
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