Key result
Aspirin before experimental aortic thrombosis cuts collateral circulation time by ~69% in cats.
Why the study?
Does aspirin improve collateral blood flow after experimental thrombosis of the feline aorta?
Population
11 cats with experimental thrombosis of the caudal aorta
Comparison
Aspirin 650 mg orally given 1 hour before aortic… vs No treatment
Design
Preclinical
Follow-up
3 hours after surgery
Authors
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Hypothesis-generating for aspirin in feline aortic thrombosis; does not support clinical practice change without further study.
Does aspirin improve collateral blood flow after experimental thrombosis of the feline aorta?
Absolute Event Rate: 2.3% vs 7.5%
Aspirin pretreatment significantly improves collateral blood flow following experimental aortic thrombosis in cats, suggesting a role for platelet thromboxane A2 in collateral inhibition.
Schaub et al. (1982) studied Experimental thrombosis of the aorta (n=11). Aspirin vs. No treatment was evaluated on Time necessary for contrast media to appear in the iliac arteries caudal to the thrombus during aortography (seconds). Aspirin administration before experimental aortic thrombosis in cats reduced the time for contrast media to appear in collateral iliac arteries to 2.3 +/- 0.3 s compared to 7.5 +/- 0.5 s in controls.
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