Key result
Aspirin but not diltiazem abolishes arachidonic acid-induced platelet aggregation in healthy cats.
Why the study?
Does diltiazem, aspirin, or their combination reduce platelet aggregation in healthy cats?
Population
Healthy cats
Comparison
Diltiazem, aspirin, or a combination of… vs Baseline values obtained prior to treatment
Design
Preclinical
Authors
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Should not guide clinical antithrombotic use in cats; hypothesis-generating for diseased models and trials.
Does diltiazem, aspirin, or their combination reduce platelet aggregation in healthy cats?
In healthy cats, aspirin inhibits arachidonic acid-induced platelet aggregation, while diltiazem has no effect on aggregation and does not alter the effect of aspirin.
Behrend et al. (1996) studied Healthy. Diltiazem, aspirin, or combination vs. Baseline values prior to treatment was evaluated on Platelet aggregation in response to collagen, arachidonic acid, and ADP. Aspirin alone or combined with diltiazem abolished platelet aggregation in response to arachidonic acid in healthy cats, whereas diltiazem alone had no effect.
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