Why the study?
Does diltiazem alone or combined with low-dose aspirin reduce platelet aggregation and ATP release in healthy volunteers?
Population
25 healthy volunteers
Comparison
Oral diltiazem for 1 week, followed by random… vs Baseline and aspirin alone for 1 week
Design
RCT, crossed over randomly
Follow-up
3 weeks (1 week per period)
Authors
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Diltiazem does not potentiate low-dose aspirin's antiplatelet effects in vivo; challenges prior in vitro data without supporting combined regimens.
Does diltiazem alone or combined with low-dose aspirin reduce platelet aggregation and ATP release in healthy volunteers?
In vivo, diltiazem partially inhibits synergistic platelet aggregation but does not potentiate the inhibitory effects of low-dose aspirin.
Zucker et al. (1993) studied this question.
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