November 1, 1984Clinical Pharmacology & Therapeutics

Effects of diltiazem, dipyridamole, and their combination on hemostasis

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Why the study?

Does diltiazem, dipyridamole, or their combination alter hemostasis in normal men?

Population

n=5 normal men

Comparison

Diltiazem or dipyridamole, with the alternate… vs Baseline and each drug alone

Follow-up

48 hours

Authors

KCKarl F. CremerRegulus Therapeutics (United States)JPJohn A. PieperUniversity of North Carolina at Chapel Hill MJMichel JoyalMontreal Heart Institute

Discussion

Member takes

Implication

Supports lack of hemostatic impact in healthy subjects; leaves open translation to clinical populations with cardiovascular disease.

Structured PICO

Does diltiazem, dipyridamole, or their combination alter hemostasis in normal men?

Population

n=5 normal men

Intervention

Diltiazem (90 mg by mouth, followed by 60 mg every 6 hr for 48 hr) or dipyridamole (75 mg by mouth every 8 hr for 48 hr), with the alternate drug added at 24 hr to assess combination effects

Comparator

Baseline and each drug alone

Outcome

Hemostasis parameters including bleeding time, prothrombin time, partial thromboplastin time, and platelet aggregationsurrogate

Diltiazem and dipyridamole, alone or in combination, do not cause clinically relevant changes in hemostasis in normal men, despite measurable in vitro inhibition of platelet aggregation.

Cite This Study

Cremer et al. (1984) studied this question.

synapsesocial.com/papers/6a7deb411a9d4ca5f9ac8dbc https://doi.org/10.1038/clpt.1984.234

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