January 1, 1991Platelets

Influence of a Single Dose of Calcium Channel Blockers on Platelet Function

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Why the study?

Does a single oral dose of calcium channel blockers (diltiazem, nifedipine, verapamil) reduce platelet aggregation and alter prostaglandin system parameters in patients with coronary artery disease?

Population

24 patients with coronary artery disease

Follow-up

90 minutes

Authors

KWKelly WeissCleveland Clinic PFP FitschaStatistics Austria IVIrene VirgoliniInnsbruck Medical University

Discussion

Member takes

Implication

May suggest antiplatelet effects of diltiazem in CAD; hypothesis-generating and should not yet change practice.

Structured PICO

Does a single oral dose of calcium channel blockers (diltiazem, nifedipine, verapamil) reduce platelet aggregation and alter prostaglandin system parameters in patients with coronary artery disease?

Population

24 patients with coronary artery disease

Intervention

Single oral dose of diltiazem (60 mg), nifedipine (10 mg) and verapamil (80 mg)

Outcome

ADP-, collagen-, and epinephrine-induced platelet aggregation, malondialdehyde formation, serum thromboxane B(2) and platelet sensitivity to PGI(2) measured 90 minutes after drug intakesurrogate

A single oral dose of calcium channel blockers, particularly diltiazem, significantly decreases ex vivo platelet function parameters in patients with coronary artery disease.

Cite This Study

Weiss et al. (1991) studied this question.

synapsesocial.com/papers/6a87a8e12e373a2e380dcf59 https://doi.org/10.3109/09537109109005501

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Influence of a Single Dose of Calcium Channel Blockers on Platelet Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Influence of a Single Dose of Calcium Channel Blockers on Platelet Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider